The asymmetry and narrow linewidth properties of the Fano lineshape are conducive to the realization of refractive index sensing with high sensitivity and low detection limit. In this paper, the coupled structure of the microring resonator and the Fabry-Perot cavity is designed based on the slot waveguide by using the three-dimensional time-domain finite-difference method. The Fano lineshape resonance is realized and utilized for refractive index sensing to improve performances of refractive index sensors. Different from reported complex structures such as multiple micro-ring cascaded, the sensitivity of 500 nm/RIU and the detection limit of 4.00×10-5 RIU are achieved under the wavelength tracking scheme based on the Fano lineshape resonance of the single slot waveguide microring resonator. The sensitivity is 7.24×104 dB/RIU and the detection limit is 5.52×10-6 RIU under the intensity tracking scheme.