The ionization of the outer space would degrade CMOS image sensor even burn at the worst. In this paper, it is represented the radiation hardened design technique from layout to circuit designing CMOS image sensor. A series of experiments have been carried out on the samples and the results show the performance of the CMOS image sensor realizing total-dose resilience up to 100 krad(Si) and single-event effect resilience up to 1x107p/cm2meeting the radiation hardened design expectation.