Abstract:As one of the key devices in photoelectric imaging systems, complementary metal oxide semiconductor (CMOS) active pixel sensors (APS) are widely used in the space or nuclear radiation environments, but the radiation damage is the main reason that causes the performance degradation of CMOS APS, and even functional failure. The physical mechanisms of the displacement, total dose, and single event effects on CMOS APS which caused by the different radiation particles or rays are presented. The experiments and damage mechanisms of the radiation damage inducing the increase of the dark signal and the noise, the decrease of the quantum efficiency and the saturation voltage, and the generation of dark signal spikes and random telegraph signal (RTS) are reviewed and analyzed. The challenges of the radiation damage effects on CMOS APS are discussed.