Based on traditional methods of single point and two-point correction, a new algorithm suitable for insufficient change scenes was proposed. Based on the correlation of multi-port image data in dynamic scene real-time imaging, the algorithm applies FPGA+ARM platform and uses the method of real-time correction of offset coefficient to realize real-time non-uniformity correction of multi-port images, resolving the problems of the adaptive adjustment of calibration algorithm and the real-time correction of scenario algorithm.