Briefly described are reliability research methods and roadmap of the PoF-based MEMS (Micro-electro-mechanical systems). Using the capacitive RF MEMS switch as an example, main steps of the method are described, including the flowing steps: to study the MEMS devicesbehaviors with the 3D multi-physics finite element models, to study the MEMS devices failure mechanism with its behavior model and the PoF experiment technology, and to establish a common MEMS device failure prediction model with some certain introduced figure of merit.