A new protection method based on fault section detection and isolation combined with centralization and dispersion is proposed. The network describing matrix is formed based on the distribution network topological structure and the reference power flow direction and the fault information matrix is defined based on the phase relationship between the voltage component and the current component. By modifying the network describing matrix with the fault information matrix, the fault judgment matrix P is formed, then fault location criterion will be adopted to look up the elements of P one by one, the fault location can be determined fast and accurately, then, tripping orders are sent out to isolate the fault region.